#017 - David Sinclair: Curing Aging, Longevity, Genes, Epigenetics, Red Wine And Resveratrol, NAD, The Methylation Clock, Fasting, Biological Vs. Ment...

The Melanie Avalon Biohacking Podcast

Melanie Avalon

Alternative Health, Nutrition, Health & Fitness

4.5 • 650 Ratings

🗓️ 28 November 2019

⏱️ 98 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Full Shownotes And Transcript: MelanieAvalon.com/lifespan Stuff I Like: MelanieAvalon.com/StuffILike 14:40 - David's Quest For Longevity 17:15 - Do Yeast And Rodent Trials Apply To Humans? 19:05 - Historical Theories Of Aging 21:45 - The (Lost) Information Theory Of Aging 22:30 - What Do Genetics And Epigenetics Look Like On A Cellular Level? 27:25 - The Piano/Pianist Gene/Epigenome Analogy 28:45 - What Is Methylation? 30:10 - The Scratched DVD Analogy For Aging 31:05 - Removing Damage Vs. Adding Back Information 36:20 - The Genetic Methylation Clock And Yamanaka Factors 38:10 - Restoring Vision 44:35 - The Role Of Damage In Aging 49:15 - Practical Implementation Of Antiaging: Fasting, Calorie Restriction, Exercise, Cold And Heat Stress 51:50 - The Role Of Sirtuins 53:00 - Are Damaged Cells More Susceptible To Damage? 55:00 - SLEEP REMEDY:Sleep Remedy Is The Ultimate Sleep Supplement, Developed By Dr. Kirk Parlsey After Years Of Research To Naturally Restore Sleep To The Sleep-Deprived, Insomniac Navy Seals. Rather Than Knocking You Out With Drugs, Sleep Remedy Provides The Necessary Neurotransmitters And Nutrients In The Perfect Amounts To Naturally Support Your Body's Sleep Process. Use The Code MELANIEAVALON At Sleepremedy.com For 10% Off!! 59:00 - Natural Molecules That Activate Longevity Genes 59:50 - Resveratrol From Wine Vs. Supplements 1:01:50 - The Longest Lived People 1:02:30 - Biological Vs Mental Stress: The Importance Of Not Worrying 1:05:10 - IF And CR: Do You Need To Feel Hungry For Lifespan Benefits? 1:08:00 - Low Energy, Hunger, Insulin, The Mitochodria, And Longevity 1:09:30 - The Role Of Metabolism And Thyroid 1:12:00 - Ketones And Longevity The Melanie Avalon Podcast Episode #4 - Paul Saladino, MD 1:13:30 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold- Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link DryFarmWines.com/Melanieavalon To Get A Bottle For A Penny! 1:15:20 - NAD For Longevity, And NMN Supplementation 1:22:10 - Fasting And Stem Cells 1:23:10 - A Thought Experiment: Living In A 200 Year Old Society

Transcript

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0:00.0	I call it the information theory of aging.
0:04.0	80% of our lifespan is determined by how we live our lives.
0:07.0	We can turn on these survival systems and epigenome stabilizers,
0:11.0	eating a lot less often.
0:13.0	You can take a Sotuan activating molecule, which is resveratrol.
0:17.0	These all work, we think, because they're turning on these defense pathways.
0:24.5	Kind of discoveries we're making, I didn't think that we'd see in my lifetime.
0:31.2	There's a backup hard drive of youthfulness and cells that we can access and essentially reset the body to the young get.
0:40.1	Welcome to the Melanie Avalon biohacking podcast, where we meet the world's top experts to explore the secrets of health,
0:43.3	mindset, longevity, and so much more.
0:47.8	Are you ready to take charge of your existence and biohack your life?
0:49.7	This show is for you.
0:59.5	Please keep in mind, we're not dispensing medical advice and are not responsible for any outcomes you may experience from implementing the tactics lying herein.
1:02.2	Are you ready? Let's do this.
1:07.2	Welcome back to the Melanie Avalon Biohacking podcast.
1:11.7	Today's episode, guys, I know I've been talking about it on the Intermittent Fasting podcast for months now. That is because I had this episode scheduled originally
1:17.9	quite a while back, booked for an hour with David Sinclair. And as it turned out,
1:22.7	if we pushed back the recording date a little bit, I could have an entire hour and a half with him.
1:28.9	Totally worth it. That's how excited I am about this interview. I just can't even describe how
1:34.5	excited I am about this interview. I don't want to make the other episodes jealous, but
1:39.9	prepping for it, recording it, everything was like the Disney World Christmas magicalness
1:48.0	of everything I could ever want in this podcast. So please enjoy it. The show notes for today's
	...

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